A new strategy to reduce the growth of lung tumors


4 febrero 2020

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iDIFFER researchers describes how lung cancers are sensitive to the elimination of p38alpha, a protein with multiple roles in the balance between cell proliferation and differentiation. The work has been published in the journal Proceedings to the National Academy of Sciences USA.

The iDIFFER lab led by Dr. Angel R. Nebreda (link to http://www.idiffer.es/the-network/dr-angel-r-nebreda/), ICREA researcher and head of the Signaling and Cell Cycle Laboratory of the Institute for Research in Biomedicine (IRB Barcelona) has just reported a new strategy to prevent lung cancer proliferation. The study shows how tumors take advantage for their progression of a protein that originally protected healthy lung cells. This molecule is a protein kinase and the results from this study may have therapeutic application since chemical compounds that inhibit the function of p38 would interfere with the growth of lung tumors. This work has a collaboration with the laboratory of Mariano Barbacid at the Spanish National Cancer Research Centre (CNIO).

Original publication:

Requirement for epithelial p38α in KRAS-driven lung tumor progression

Jessica Vitos-Faleato, Sebastián M Real, Nuria Gutierrez-Prat, Alberto Villanueva, Elisabet Llonch, Matthias Drosten, Mariano Barbacid, Angel R Nebreda.

Proc Natl Acad Sci U S A . 2020 Feb 4;117(5):2588-2596.

The image shows immunodetection of the protein p38alpha in early lesions in lung cancer (Taken from Vitos-Faleato et al., PNAS 2020.